Lopend onderzoek en publicaties Longeneeskunde

Lopend onderzoek

• ExCluSie-F2
  Phenotyping and classifying of adult asthma exacerbations: towards future personalized treatment - a multicenter observational cohort study

Publicaties

• The effect of a systematic multidimensional assessment in severe uncontrolled asthma: a literature review and protocol for an investigator-initiated, open-label, randomized-controlled trial (EXACT@home study) https://pubmed.ncbi.nlm.nih.gov/40382637/ Bult L, Braunstahl GJ, Aerts JGJV, Bänffer D, van Campen JSJA, van Daalen MS, van Dooren Y, Flanders U, Geurts ES, Hekking PP, HellerBaan R, Jans MJA, Kappen JH, Mies RCA, Oppedijk B, de la Roij-Hartmans M, Van der Sar-Van der Brugge S, Türk Y, Vis E, Wolters R, Vasbinder EC, Veen JCCMI'. Affiliations Bravis BMC Pulm Med. 2025 May 17;25(1):240. doi: 10.1186/s12890025-03646-5. PMID: 40382637
   
• High-flow nasal oxygen vs. conventional oxygen therapy in patients with COVID-19 related acute hypoxemic respiratory failure and a do not intubate order: a multicentre cohort study. https://pubmed.ncbi.nlm.nih.gov/40281556/ 
  Sjauw DJT, Hessels LM, Duiverman ML, Elshof J, Janssen ML, Türk Y, Heunks L, Baart SJ, Wils EJ; Dutch HFNO study group; NORMO2 project group. Collaborator Rogier A S Hoek Respir Res. 2025 Apr 25;26(1):161. PMID: 40281556 PMCID: PMC12032817 Doi: 10.1186/s12931-025-03231-8.

• mRNA-based COVID-19 vaccination of lung transplant recipients with prior SARS-CoV-2 infection induces durable SARS-CoV-2-specific antibodies and T cells. https://pubmed.ncbi.nlm.nih.gov/39226789/ Liu S, van Dijk LLA, den Hartog Y, Hoek R, Verschuuren E, Geurtsvankessel CH, de Vries RD, Van Baarle D, Buter CVL. 
  Vaccine. 2024 Oct 24;42(24):126250. doi: 10.1016/j.vaccine.2024.126250. Epub 2024 Sep 2. PMID: 39226789

• Severe COPD: Multidisciplinary Consultation to Get the Right Care at the Right Place. https://pubmed.ncbi.nlm.nih.gov/38500556/ Hekking PP, van Meggelen M, Lie WJ, Hoek RAS, van Ranst D, van der Kleij SCJ, Seghers L, Kappen J, Braunstahl GJ, In 't Veen J; Severe Asthma & COPD Network South West Netherlands. Int J Chron Obstruct Pulmon Dis. 2024 Mar 14;19:749-752. doi: 10.2147/COPD.S434011. eCollection 2024. PMID: 38500556

• Humoral and cellular immune responses after COVID-19 vaccination of lung transplant recipients and patients on the waiting list: a 6-month follow-up. https://pubmed.ncbi.nlm.nih.gov/38239369/ Hoek RAS, Liu S, GeurtsvanKessel CH, Verschuuren EAM, Vonk JM, Hellemons ME, Kool M, Wijbenga N, Bogers S, Scherbeijn S, Rugebregt S, van Gemert JP, Steenhuis WN, Niesters HGM, van Baarle D, de Vries RD, Van Leer Buter C. Front Immunol. 2024 Jan 4;14:1254659. PMID: 38239369 PMCID: PMC10794507 DOI: 10.3389/fimmu.2023.1254659

• Effect of rotational thromboelastometry-guided bleeding management in bilateral lung transplantation. https://pubmed.ncbi.nlm.nih.gov/40145117/ Karrar S, Filius A, Langmuur SJ, Mahtab EA, Hoek R, Hoeks SE, Hellemons ME, Ter Horst M. PMID: 40145117 PMCID: PMC11935446 DOI: 10.1016/j.jhlto.2024.100055

• Safety and Outcome of High-Flow Nasal Oxygen Therapy Outside ICU Setting in Hypoxemic Patients With COVID-19. https://pubmed.ncbi.nlm.nih.gov/37855812/ Janssen ML, Türk Y, Baart SJ, Hanselaar W, Aga Y, van der Steen-Dieperink M, van der Wal FJ, Versluijs VJ, Hoek RAS, Endeman H, Boer DP, Hoiting O, Hoelters J, Achterberg S, Stads S, Heller-Baan R, Dubois AVF, Elderman JH, Wils EJ; Dutch HFNO COVID-19 Study Group. Crit Care Med. 2024 Jan 1;52(1):31-43. doi: 10.1097/CCM.0000000000006068. Epub 2023 Oct 19. PMID: 37855812

• Detection of Bacterial Colonization in Lung Transplant Recipients Using an Electronic Nose. https://pubmed.ncbi.nlm.nih.gov/37745948/ Wijbenga N, de Jong NLA, Hoek RAS, Mathot BJ, Seghers L, Aerts JGJV, Bos D, Manintveld OC, Hellemons ME.
  Transplant Direct. 2023 Sep 20;9(10):e1533. doi: 10.1097/TXD.0000000000001533. eCollection 2023 Oct. PMID: 37745948

• Diagnostic accuracy of eNose 'breathprints' for therapeutic drug monitoring of Tacrolimus trough levels in lung transplantation. https://pubmed.ncbi.nlm.nih.gov/37582348/ Wijbenga N, Muller MM, Hoek RAS, Mathot BJ, Seghers L, Aerts JGJV, de Winter BCM, Bos D, Manintveld OC, Hellemons ME. J Breath Res. 2023 Sep 5;17(4). doi: 10.1088/1752-7163/acf066.
  PMID: 37582348
   
• Current Perspectives on the Management of Herpesvirus Infections in Solid Organ Transplant Recipients. https://pubmed.ncbi.nlm.nih.gov/37515280/ Malahe SRK, van Kampen JJA, Manintveld OC, Hoek RAS, den Hoed CM, Baan CC, Kho MML, Verjans GMGM. Viruses. 2023 Jul 21;15(7):1595. doi: 10.3390/v15071595. PMID: 37515280

• The effect of beclomethasone-formoterol versus placebo on chronic cough in patients with non-CF bronchiectasis: the FORZA randomised controlled trial. https://pubmed.ncbi.nlm.nih.gov/37263749/ van der Veer T, de Koning Gans JM, Braunstahl GJ, Pieters ALP, van den Berg JMW, Hoek RAS, Kamphuis LSJ, Bakker M, Dubois AVF, Aerts JGJV, van der Eerden MM. Eur Respir J. 2023 Jun 29;61(6):2300186. doi: 10.1183/13993003.00186-2023. Print 2023 Jun. PMID: 37263749

• Epidemiology and management of nontuberculous mycobacterial disease in people with cystic fibrosis, the Netherlands. https://pubmed.ncbi.nlm.nih.gov/36347785/  Zomer D, van Ingen J, Hofland R; Dutch CF Registry Steering group. Collaborator RAS Hoek. J Cyst Fibros. 2023 Mar;22(2):327-333. doi: 10.1016/j.jcf.2022.10.009. Epub 2022 Nov 6. PMID: 36347785

• Diagnostic performance of electronic nose technology in chronic lung allograft dysfunction. https://pubmed.ncbi.nlm.nih.gov/36283951/ Wijbenga N, Hoek RAS, Mathot BJ, Seghers L, Moor CC, Aerts JGJV, Bos D, Manintveld OC, Hellemons ME. 
  J Heart Lung Transplant. 2023 Feb;42(2):236-245. doi: 10.1016/j.healun.2022.09.009. Epub 2022 Sep 20. PMID: 36283951

• Clinical Characteristics and Outcomes of Immunocompromised Patients With Coronavirus Disease 2019 Caused by the Omicron Variant: A Prospective, Observational Study. https://pubmed.ncbi.nlm.nih.gov/35869843/ Hoek RAS, Malahe SRK, Dalm VASH, Broers AEC, den Hoed CM, Manintveld OC, Baan CC, van Deuzen CM, Papageorgiou G, Bax HI, Van Kampen JJ, Hellemons ME, Kho MML, de Vries RD, Molenkamp R, Reinders MEJ, Rijnders BJA. Clin Infect Dis. 2023 Feb 8;76(3):e172-e178. doi: 10.1093/cid/ciac571. PMID: 35869843

• The development of the ADO-SQ model to predict 1-year mortality in patients with COPD. (https://pubmed.ncbi.nlm.nih.gov/35331047/). Owusuaa C, van der Leest C, Helfrich G, Heller-Baan R, Loenhout CV, Herbrink JW, Nieboer D, van der Rijt CC, van der Heide A. Palliat Med. 2022 May;36(5):821-829. doi: 10.1177/02692163221080662. Epub 2022 Mar 24. PMID: 35331047; PMCID: PMC9087317
   
• Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. (https://pubmed.ncbi.nlm.nih.gov/35247983/). Henkens MTHM, Raafs AG, Verdonschot JAJ, Linschoten M, van Smeden M, Wang P, van der Hooft BHM, Tieleman R, Janssen MLF, Ter Bekke RMA, Hazebroek MR, van der Horst ICC, Asselbergs FW, Magdelijns FJH, Heymans SRB; CAPACITY-COVID collaborative consortium: van Boxem AJM. BMC Geriatr. 2022 Mar 5;22(1):184. doi: 10.1186/s12877-021-02673-1. PMID: 35247983
   
• Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries. (https://pubmed.ncbi.nlm.nih.gov/34734634/). CAPACITY-COVID Collaborative Consortium and LEOSS Study Group: van Boxem AJM. Eur Heart J. 2022 Mar 14;43(11):1104-1120. doi: 10.1093/eurheartj/ehab656. PMID: 34734634
   
• Dissemination of localized Mycobacterium malmoense infection in an immunocompromised patient (https://pubmed.ncbi.nlm.nih.gov/30201506/). Zweijpfenning SMH, Schipper L, Duurkens VAM, Harbers JB, van Ingen J, Hoefsloot W. Int J Infect Dis. 2018 Nov;76:35-37. doi: 10.1016/j.ijid.2018.08.019. Epub 2018 Sep 7.