Lopend onderzoek en publicaties MDL

Lopend onderzoek

• MISSION
  Multicenter, gerandomiseerde studie naar de effectiviteit van oraal metamizol bij pijn bij chronische pancreatitis, gemeten via de gemiddelde dagelijkse pijnscore gedurende 4 weken behandeling.
  Lokale hoofdonderzoeker: Parweez Koehestanie
• PIANO trial
  Precision use of antibiotics in infected necrotizing pancreatitis
  Lokale hoofdonderzoeker: Parweez Koehestanie
• RELIEF trial 
  RELIEF-pathway in patients with upper abdominal pain; an open-label multicenter randomized controlled trial 
  Lokale hoofdonderzoeker: Merel Tielemans
• PLANCTON trial
  Pancreatitis and early omega-3-fatty acid infusion for reduction of organ failure and mortality
  Lokale hoofdonderzoeker: Parweez Koehestanie
• PICUS-2
  Preventing recurrent ‘idiopathic’ acute pancreatitis through laparoscopic cholecystectomy (PICUS-2): a multicenter randomized trial’
  Lokale hoofdonderzoeker: Kim van Boxtel
• Dutch-TIMELINES
  Dutch NaTional ImpleMEntation of choLecystectomy <72h after ERCP forcommoN bilE duct StoneS

Publicaties

• Computed Tomography Colonography in Fecal Immunochemical Test Positives in a Colorectal Cancer Screening Program. (https://pubmed.ncbi.nlm.nih.gov/40345412/). Sarah Moen, Fleur E Marijnissen, Jochim S Terhaar Sive Droste, Wouter H de Vos Tot Nederveen Cappel, B W Marcel Spanier, Jelle F Huisman, Evelien Dekker, Jaap Stoker, Ernst J Kuipers, Maarten G J Thomeer, Manon C W Spaander; CT in BVO Study Group: Leonieke M M Wolters, Ivonne Leeuwenburgh, Merel M Tielemans, Xander G Vos, Mariette C A van Kouwen, Marjon Kerkhof, Ruud W M Schrauwen, Renzo P Veenstra, Lisette G Capelle, Marloes Bigirwamungu-Bargeman, Caroline A Wientjes, Conny van Enckevort, Sanna A Mulder, Djuna L Cahen, Tom C Seerden, Lennard P L Gilissen, Robbert Eichhorn, Paul Bus, Rogier J J de Ridder, Erik H C J Buster, Annick B van Nunen. Clin Gastroenterol Hepatol. 2025 Dec;23(13):2616-2624.e3. doi: 10.1016/j.cgh.2025.03.009. Epub 2025 May 7. PMID: 40345412
   
• Effectiveness and tolerability of bezafibrate in primary biliary cholangitis - a nationwide real-world study. (https://pubmed.ncbi.nlm.nih.gov/41363724/). Maria C van Hooff, Rozanne C de Veer, Ellen Werner, Ulrich Beuers, Joost P H Drenth, Frans J C Cuperus, Bart van Hoek, Bart J Veldt, Michael Klemt-Kropp, Suzanne van Meer, Robert C Verdonk, Hajo J Flink, Jan M Vrolijk, Tom J G Gevers, Cyriel Y Ponsioen, Janne E van Rooij, Marjo J Kerbert-Dreteler, Jerome Sint Nicolaas, J Marleen de Vree, Elsemieke S de Vries, Philip W Friederich, Merel M Tielemans, Huseyin Aktas, Daphne M Hotho, Ulrike de Wit, Johan P H Kuyvenhoven, Sunje Abraham, Edith M M Kuiper, Stephan Schmittgens, Yasser A Alderlieste, Ynte S de Boer, Harry L A Janssen, Bettina E Hansen, Nicole S Erler, Adriaan J van der Meer. Am J Gastroenterol. 2025 Dec 9. doi: 10.14309/ajg.0000000000003879. Online ahead of print PMID: 41363724
   
• Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis. (https://pubmed.ncbi.nlm.nih.gov/40912695/).  Hannah S Pauw, Hester C Timmerhuis, Marc G Besselink, Yama Issa, Marco Bruno, Pieter Jan Floris de Jonge, Harry van Goor, Erwin-Jan M van Geenen, Rutger Quispel, Wim van de Vrie, Adriaan Tan, Muhammed Hadithi, Niels G Venneman, J M Jansen, Ben J Witteman, Matthijs P Schwartz, Roy L J van Wanrooij, Rogier P Voermans, Alexander C Poen, Peter van Duijvendijk, Marie Paule G F Anten, Tessa Römkens, Elske Sieswerda, Merel M Tielemans, Jeanin E van Hooft, Marja A Boermeester, Robert C Verdonk, Hjalmar C van Santvoort, Fons F van den Berg. BMJ Open Gastroenterol. 2025 Sep 5;12(1):e001961. doi: 10.1136/bmjgast-2025-001961. PMID: 40912695; PMCID: PMC12414194
   
• Revised Guidelines for the Treatment and Follow-Up of Gallbladder Polyps Do Not Reduce Unwarranted Cholecystectomies: Results of the POLYP Study. (https://pubmed.ncbi.nlm.nih.gov/40697033/)
  Mike van Dooren, Elise A J de Savornin Lohman, Jarmila van der Bilt, Marieke T de Boer, Djamila Boerma, Philip Bos, Andries E Braat, Steve M M de Castro, Bartholomeus J G A Corten, Freek Daams, Joris I Erdmann, Floris Ferenschild, Ansje S Fortuin, Nanette van Geloven, Erik van der Hoeven, Rutger Klicks, Flip M Kruyt, Barbara S Langenhoff, Mike S L Liem, Philip V M Linsen, Misha Luyer, Vincent B Nieuwenhuijs, Pim Olthof, Peter W Plaisier, Charles van Rossem, Ruud Schrauwen, Jennifer Schreinemakers, Gian Piero Serafino, Ernst Jan Spillenaar Bilgen, Koen Talsma, Merel M Tielemans, Charlotte J Tutein Nolthenius, Philip de Reuver.  United European Gastroenterol J. 2025 Sep;13(7):1133-1140. Epub 2025 Jul 23. PMID: 40697033 PMCID: PMC12463707 DOI: 10.1002/ueg2.70057
   
• Reducing outpatient visits for FIT-positive participants of colorectal cancer screening programs with home-based digital counselling. (https://pubmed.ncbi.nlm.nih.gov/40374884/)
  Fleur E Marijnissen, Elyse E C Rijnders, Merel M Tielemans, Désiree van Noord, Leonieke M M Wolters, Jeroen M Jansen, Ingrid Schot, Frank C Bekkering, Agnes N Reijm, Sophia M van Baalen, Tingting Wang, Marijke Melles, Richard Goossens, Sohal Y Ismail, Iris Lansdorp-Vogelaar, Pieter Jan F de Jonge, Manon C W Spaander. NPJ Digit Med. 2025 May 15;8(1):285. doi: 10.1038/s41746-025-01683-2. PMID: 40374884
   
• Alarm symptoms and the risk of upper gastrointestinal cancer in patients below the age of 60. (https://pubmed.ncbi.nlm.nih.gov/40221298/). Theunissen F, Ter Borg PCJ, Ouwendijk RJT, Bruno MJ, Siersema PD; Trans.IT Foundation Study Group: van Leerdam ME, Kubben FJGM, Rasica M, Uil JJ, Kerkhof M, Slangen RME, Bus PJ, Thijs WJ, Groenen MJM, van Hoboken E, Bruins Slot W, Wormmeester L, Vleggaar F, Noach LA, Kuipers EJ. Dig Liver Dis. 2025 Jul;57(7):1481-1486. doi: 10.1016/j.dld.2025.03.026. Epub 2025 Apr 11. PMID: 40221298
   
• The effect of prophylactic clipping on delayed bleeding after proximal colonic endoscopic mucosal resection: a multicenter, randomized controlled trial (CLIPPER). (https://pubmed.ncbi.nlm.nih.gov/40695477/). Gijs Kemper, Ayla S Turan, Ramon-Michel Schreuder, Ruud W M Schrauwen, Muhammed Hadithi, Paul Didden, Barbara A J Bastiaansen, Bas W van der Spek, Jochim S Terhaar Sive Droste, Matthijs P Schwartz, Wouter L Hazen, Jan Willem A Straathof, Jurjen J Boonstra, Alaa Alkhalaf, Fia J Voogd, Daud Allajar, Wilmar de Graaf, Parweez Koehestanie, Robert Roomer, Rogier J J de Ridder, Leon M G Moon, Peter D Siersema, Erwin J M van Geenen. Endoscopy. 2025 Nov;57(11):1243-1250. doi: 10.1055/a-2637-3180. Epub 2025 Jul 22. PMID: 40695477
   
• Recurrence after piecemeal hot-snare endoscopic mucosal resection of 10-20-mm nonpedunculated colorectal polyps: a multicenter cohort study. (https://pubmed.ncbi.nlm.nih.gov/40112831/). Michiel H J Maas, Yark Hazewinkel, Jochim S Terhaar Sive Droste, Ruud W M Schrauwen, Adriaan C Tan, Parweez Koehestanie, Mariëtte C A van Kouwen, Peter D Siersema. Endoscopy. 2025 Jul;57(7):740-749. doi: 10.1055/a-2563-1606. Epub 2025 Mar 20. PMID: 40112831; PMCID: PMC12224662
   
• Incidence and prevalence of primary biliary cholangitis in the Netherlands - A nationwide cohort study(https://pubmed.ncbi.nlm.nih.gov/39113899/) 
  Rozanne C de Veer 1, Maria C B van Hooff 1, Ellen Werner 1, Ulrich Beuers 2, Joost P H Drenth 3, Frans J C Cuperus 4, Bart van Hoek 5, Bart J Veldt 6, Michael Klemt-Kropp 7, Suzanne van Meer 8, Robert C Verdonk 9, Hajo J Flink 10, Jan Maarten Vrolijk 11, Tom J G Gevers 12, Cyriel Y Ponsioen 2, Martijn J Ter Borg 13, Khalida Soufidi 14, Femke Boersma 15, Hendrik J M de Jonge 16, Frank H J Wolfhagen 17, L C Baak 18, Susanne L Onderwater 19, Jeroen D van Bergeijk 20, Paul G van Putten 21, Gijs J de Bruin 22, Rob P R Adang 23, Maria N Aparicio-Pages 24, Wink de Boer 25, Frank Ter Borg 26, Hanneke van Soest 27, Harry L A Janssen 1 28, Bettina E Hansen 29 30, Nicole S Erler 29 30, Adriaan J van der Meer 1; Dutch PBC Study Group Collaborators, Affiliations Collapse Collaborators Merel M Tielemans JHEP Rep. 2024 Jun 6;6(8):101132. doi: 10.1016/j.jhepr.2024.101132. eCollection 2024 Aug. PMID: 39113899
   
• Therapeutic drug monitoring of methotrexate in patients with Crohn’s disease. (https://pubmed.ncbi.nlm.nih.gov/37767910/). van de Meeberg MM, Fidder HH, Oldenburg B, Sundaresan J, Struys EA, Montazeri NSM, Mares WGM, Mahmmod N, van Asseldonk DP, Lutgens MWMD, Kuyvenhoven JP, Rietdijk ST, Nissen LHC, Koehestanie P, de Boer NKH, de Jonge R, Bouma G, Bulatović Ćalasan M, Dutch Initiative on Crohn and Colitis (ICC). Aliment Pharmacol Ther. 2023 Dec;58(11-12):1151-1162. doi: 10.1111/apt.17719. Epub 2023 Sep 28
   
• Clip placement does not prevent delayed bleeding after endoscopic mucosal resection (clipper) for large polyps in the proximal colon: a multicenter, randomized controlled trial. (https://www.giejournal.org/article/S0016-5107(23)01098-2/abstract). Kemper G,Turan A, Schreuder RM, Schrauwen R, Hadithi M, Didden P, Bastiaansen B, Van Der Spek B, Terhaar JS, Droste S, Schwartz M, Hazen W, Straathof JW, Boonstra J, Alkhalaf A, Voogd FJ, Allajar D, de Graaf W,  Koehestanie P, Roomer R,  De Ridder R, Moons LMG, Siersema P, Van Geenen EJ. Gastrointestinal Endoscopy Volume 97, Issue 6, Supplement, June 2023, Page AB220. doi: 10.1016/j.gie.2023.04.712
   
• Caries explosion following bariatric surgery (https://pubmed.ncbi.nlm.nih.gov/31522209/). Klüter WJ, Koehestanie P, de Baat C. Ned Tijdschr Tandheelkd. 2019 Sep;126(9):437-441. doi: 10.5177/ntvt.2019.09.19054