Lopend onderzoek en publicaties Interne Geneeskunde

Lopend onderzoek

• Predict
  PERCUTANEOUS PERITONEAL DIALYSIS CATHETER INSERTION
• The Renal life cycle trial
  Renal life cycle trial; A Randomized Controlled Clinical Trial to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients with Severe Chronic Kidney Disease
• PREDICT Prospectief
  Prospective observational cohort study on the outcomes of percutaneous inserted PD catheters
• DCE PCSK9i
  A discrete choice experiment on patient preferences for PCSK9 inhibitors
• GCT3013-05
  A Randomized, Open-label, Phase 3 Trial of Epcoritamab vs Investigator’s Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma
• OCEAN(a)
  A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)
• REDEFINE 1
  Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity
• TECH
  Telemonitoring and E-Coaching in Hypertension

Publicaties 

• Health economic outcomes and costs of CDK4/6 inhibitor use in first- versus second-line for advanced breast cancer: A cost-effectiveness analysis of the phase 3 SONIA trial (https://pubmed.ncbi.nlm.nih.gov/41207182/). Noor Wortelboer, Seamus Kent, Inge R Konings, Annemiek van Ommen-Nijhof, Vincent van der Noort, Esther van den Pol, Cristina Guerrero Páez, Marlies L van Bekkum, Franchette W P J van den Berkmortel, Helga J Droogendijk, Danny Houtsma, Hendrika M Oosterkamp, Annemieke van der Padt-Pruijsten, Ester J M Siemerink, Jolien Tol, Annette A van Zweeden, A Elise van Leeuwen-Stok, Gabe S Sonke, Agnes Jager, Hedwig M Blommestein. PMID: 41207182. DOI: 10.1016/j.ejca.2025.116051
   
• Pilot bij ouderen met multipel myeloom: Veilige oncologische zorg aan huis. Auteurs: Maartje van der Klooster, Eline J. Mertens, Damien S.E. Broekharst, Sjaak Bloem, Nathascha Hanzen, Nicole de Graauw, Saskia Claassen, Lonneke Suykerbuyk, Heleen Vroman, Mariet Raatgever. Oncologica. 2025 Special V&VN Oncologiedagen, jaargang 42, nummer 3.
   
• Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study. (https://pubmed.ncbi.nlm.nih.gov/40466468/). Knikman JE, de With M, Heersche N, Lopez-Yurda M, Baars A, Creemers GJ, Droogendijk HJ, Fiets E, Imholz ALT, Iersel LV, Mandigers CMPW, van de Vendel AJ, Jeurissen FJF, Nieboer P, Deenen MJ, van de Poel MHW, Wymenga MNM, van Schaik RHN, van den Bosch BJC, Hoop EO, Rosing H, Swen JJ, Gelderblom H, Schellens JHM, Beijnen JH, Mathijssen RHJ, Guchelaar HJ, Cats A. Eur J Cancer. 2025 Apr 30;224:115483. doi: 10.1016/j.ejca.2025.115483. Online ahead of print. PMID: 40466468
   
• First-Line Systemic Treatment for Initially Unresectable Colorectal Liver Metastases: Post Hoc Analysis of the CAIRO5 Randomized Clinical Trial. (https://pubmed.ncbi.nlm.nih.gov/39570583/). Bond MJG, Bolhuis K, Loosveld OJL, de Groot JWB, Droogendijk H, Helgason HH, Hendriks MP, Klaase JM, Kazemier G, Liem MSL, Rijken AM, Verhoef C, de Wilt JHW, de Jong KP, Gerhards MF, van Amerongen MJ, Engelbrecht MRW, van Lienden KP, Hermans JJ, Molenaar IQ, Grünhagen DJ, de Valk B, Haberkorn BCM, Kerver ED, Erdkamp F, van Alphen RJ, Mathijssen-van Stein D, Komurcu A, May AM, Swijnenburg RJ, Punt CJA; Dutch Colorectal Cancer Group. JAMA Oncol. 2025 Jan 1;11(1):36-45. doi: 10.1001/jamaoncol.2024.5174. PMID: 39570583 Clinical Trial.
   
• Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD. https://pubmed.ncbi.nlm.nih.gov/39148102/ Knikman JE, Zhai Q, Lunenburg CATC, Henricks LM, Böhringer S, van der Lee M, de Man FM, Offer SM, Shrestha S, Creemers GJ, Baars A, Dezentjé VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, van Schaik RHN, Gelderblom H, Mathijssen RHJ, Schellens JHM, Cats A, Guchelaar HJ, Swen JJ.Genome Med. 2024 Aug 15;16(1):101. doi: 10.1186/s13073-024-01354-z.PMID: 39148102
   
• Survival of Patients With Cancer With DPYD Variant Alleles and DoseIndividualized Fluoropyrimidine Therapy-A Matched-Pair Analysis. https://pubmed.ncbi.nlm.nih.gov/37639651/ Knikman JE, Wilting TA, LopezYurda M, Henricks LM, Lunenburg CATC, de Man FM, Meulendijks D, Nieboer P, Droogendijk HJ, Creemers GJ, Mandigers CMPW, Imholz ALT, Mathijssen RHJ, Portielje JEA, Valkenburg-van Iersel L, Vulink A, van der Poel MHW, Baars A, Swen JJ, Gelderblom H, Schellens JHM, Beijnen JH, Guchelaar HJ, Cats A.J Clin Oncol. 2023 Dec 10;41(35):5411-5421. doi: 10.1200/JCO.22.02780. Epub 2023 Aug 28.PMID: 37639651
   
• First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group. https://pubmed.ncbi.nlm.nih.gov/37329889/ Bond MJG, Bolhuis K, Loosveld OJL, de Groot JWB, Droogendijk H, Helgason HH, Hendriks MP, Klaase JM, Kazemier G, Liem MSL, Rijken AM, Verhoef C, de Wilt JHW, de Jong KP, Gerhards MF, van Amerongen MJ, Engelbrecht MRW, van Lienden KP, Molenaar IQ, de Valk B, Haberkorn BCM, Kerver ED, Erdkamp F, van Alphen RJ, Mathijssen-van Stein D, Komurcu A, Lopez-Yurda M, Swijnenburg RJ, Punt CJA; Dutch Colorectal Cancer Study Group.
  Lancet Oncol. 2023 Jul;24(7):757-771. doi: 10.1016/S1470-2045(23)00219-X. Epub 2023 Jun 14. PMID: 37329889
   
• Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosishttps://pubmed.ncbi.nlm.nih.gov/38079324/ Smit KC, Derksen JWG, Stellato RK, VAN Lanen AS, Wesselink E, Belt EJT, Balen MC, Coene PPLO, Dekker JWT, DE Groot JW, Haringhuizen AW, VAN Halteren HK, VAN Heek TT, Helgason HH, Hendriks MP, DE Hingh IHJT, Hoekstra R, Houtsma D, Janssen JJB, Kok N, Konsten JLM, Los M, Meijerink MR, Mekenkamp LJM, Peeters KCMJ, Polée MB, Rietbroek RC, Schiphorst AHW, Schrauwen RWM, Schreinemakers J, Sie MPS, Simkens L, Sonneveld EJA, Terheggen F, Iersel LV, Vles WJ, Wasowicz-Kemps DK, DE Wilt JHW, Kok DE, Winkels RM, Kampman E, VAN Duijnhoven FJB, Koopman M, May AM.Med Sci Sports Exerc. 2024 Apr 1;56(4):623-634. doi: 10.1249/MSS.0000000000003351. Epub 2023 Nov 27.PMID: 38079324
   
• Automated peritoneal dialysis versus continuous ambulatory peritoneal dialysis for people with kidney failure https://pubmed.ncbi.nlm.nih.gov/39258519/   
  Esmee Driehuis, Marga Eshuis, Alferso Abrahams, Karlien François, Robin Wm Vernooij PMID: 39258519 PMCID: PMC11388675 (available on 2025-09-11) DOI: 10.1002/14651858.CD006515.pub2
   
• Association between cognitive functioning and health-related quality of life and its mediation by depressive symptoms in older patients with kidney failure. https://pubmed.ncbi.nlm.nih.gov/39327357/ Demirhan I, van Oevelen M, Skalli Z, Voorend CGN, Mooijaart SP, Meuleman Y, Verhaar MC, Bos WJW, van Buren M, Abrahams AC; Collaborators; Eshuis M. ; DIALOGICA study group. J Nephrol. 2024 Sep;37(7):1939-1948. doi: 10.1007/s40620-024-02095-3. Epub 2024 Sep 26. PMID: 39327357; PMCID: PMC11519205.
   
• Prevalence and Association of Pruritus and its Current Treatment during the First Year of Dialysis: A Dutch Nocturnal and Home Dialysis Study to Improve Clinical Outcomes Study. https://pubmed.ncbi.nlm.nih.gov/39453829/. Van Lieshout TS, Driehuis E, Abrahams AC, de Ruijter V, de Lange SJ, Bonenkamp AA, De Vriese AS, Vernooij RWM, Kemperman PMJH, Rustemeyer T, van Ittersum FJ, Penne EL, van Jaarsveld BC; Collaborators; Eshuis M.  DOMESTICO study group. Kidney360. 2025 Jan 1;6(1):95-104. doi: 10.34067/KID.0000000615. Epub 2024 Oct 16. PMID: 39453829; PMCID: PMC11793175.
   
• Quality of life gains in frail and intermediatefit patients with multiple Myeloma: Findings from the prospective HOVON123 clinical trial. https://pubmed.ncbi.nlm.nih.gov/38870747/ Seefat MR, Stege CAM, LissenbergWitte BI, Levin MD, Timmers GJ, Hoogendoorn M, Ypma PF, Klein SK, Velders GA, Westerman M, Strobbe L, Durdu-Rayman N, Davidis-van Schoonhoven MA, van Kampen RJW, Dijk AC, Koster A, Silbermann MH, van der Spek E, Beeker A, Erjavec Z, de Graauw NCHP, Leys MBL, Sonneveld P, van de Donk NWCJ, Nasserinejad K, Blommestein HM, Cucchi DGJ, Zweegman S. Eur J Cancer. 2024 Aug;207:114153. doi: 10.1016/j.ejca.2024.114153. Epub 2024 Jun 6. PMID: 38870747.
   
• Antihypertensive drug concentration measurement combined with personalized feedback in resistant hypertension: a randomized controlled trial. (https://pubmed.ncbi.nlm.nih.gov/37796233/). Peeters LEJ, Kappers MHW, Hesselink DA, van der Net JB, van de Laar R, Ezzahti M, van de Ven PJG, van der Meer IM, de Bruijne ELE, Indhirajanti-Tomasoa S, van der Linde NAH, Bahmany S, Boersma E, Massy EK, van Dijk L, van Gelder T, Koch BCP, Versmissen J. Journal of Hypertension 2024 Jan 1; 42 (1):169-178. doi: 10.1097/HJH.0000000000003585. Epub 2023 Oct 18.
   
• Prevention and management of kidney graft failure. Bunthof K. (https://repository.ubn.ru.nl/handle/2066/296446). doi: 10.54195 / 9789493296213
   
• Can We Predict Graft Intolerance Syndrome After Kidney Transplant Failure? External Validation of a Previously Developed Model. (https://pubmed.ncbi.nlm.nih.gov/37213489/). Bunthof K, Saboerali K, Wetering JV, Nurmohamed A, Bemelman F, Zuilen AV, Brand JVD, Baas M, Hilbrands L. Transpl Int. 2023 May 5;36:11147. doi: 10.3389/ti.2023.11147. PMID: 37213489; PMCID: PMC10195885.
   
• Health-related quality of life, psychological distress, and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy. (https://pubmed.ncbi.nlm.nih.gov/35804188/). van der Doelen MJ, Oving IM, Wyndaele DNJ, van Basten JP, Terheggen F, van de Luijtgaarden ACM, Oyen WJG, van Schelven WD, van den Berkmortel F, Mehra N, Janssen MJR, Prins JB, Gerritsen WR, Custers JAE, van Oort IM.Prostate Cancer Prostatic Dis. 2023 Mar;26(1):142-150. doi: 10.1038/s41391-022-00569-8. Epub 2022 Jul 8.PMID: 35804188
   
• Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer. (https://pubmed.ncbi.nlm.nih.gov/35205748/). Smit KC, Derksen JWG, Beets GLO, Belt EJT, Berbée M, Coene PPLO, van Cruijsen H, Davidis MA, Dekker JWT, van Dodewaard-de Jong JM, Haringhuizen AW, Helgason HH, Hendriks MP, Hoekstra R, de Hingh IHJT, IJzermans JNM, Janssen JJB, Konsten JLM, Los M, Mekenkamp LJM, Nieboer P, Peeters KCMJ, Peters NAJB, Pruijt HJFM, Quarles van Ufford-Mannesse P, Rietbroek RC, Schiphorst AHW, Schouten van der Velden A, Schrauwen RWM, Sie MPS, Sommeijer DW, Sonneveld DJA, Stockmann HBAC, Tent M, Terheggen F, Tjin-A-Ton MLR, Valkenburg-van Iersel L, van der Velden AMT, Vles WJ, van Voorthuizen T, Wegdam JA, de Wilt JHW, Koopman M, May AM, On Behalf Of The Plcrc Study Group. Cancers (Basel). 2022 Feb 16;14(4):1001. doi: 10.3390/cancers14041001. PMID: 35205748; PMCID: PMC8870120
   
• Health-related quality of life, psychological distress, and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy. (https://pubmed.ncbi.nlm.nih.gov/35804188/). van der Doelen MJ, Oving IM, Wyndaele DNJ, van Basten JP, Terheggen F, van de Luijtgaarden ACM, Oyen WJG, van Schelven WD, van den Berkmortel F, Mehra N, Janssen MJR, Prins JB, Gerritsen WR, Custers JAE, van Oort IM. Prostate Cancer Prostatic Dis. 2022 Jul 8. doi: 10.1038/s41391-022-00569-8. Online ahead of print. PMID: 35804188
   
• Monoclonal gammopathy of renal significance presenting with cryoblobulinaemia type I associaeted sever thrombotic microangiopathy. (https://pubmed.ncbi.nlm.nih.gov/35756736/). Hesius E, Bunthof KLW, Steenbergen E, de Kort E, Klein I, Wetzels J. Clin Kidney J. 2022 Mar 12;15(7):1425-1428. doi: 10.1093/ckj/sfac078. eCollection 2022 Jul. PMID: 35756736; PMCID: PMC9217659
   
• A randomized crossover study comparing different tacrolimus formulations to reduce intrapatient variability in tacrolimus exposure in kidney transplant recipients. (https://pubmed.ncbi.nlm.nih.gov/34905302/). Bunthof KLW, Al-Hassany L, Nakshbandi G, Hesselink DA, van Schaik RHN, Ten Dam MAGJ, Baas MC, Hilbrands LB, van Gelder T. Clin Transl Sci. 2022 Apr;15(4):930-941. doi: 10.1111/cts.13206. PMID: 34905302; PMCID: PMC9010272
   
• Diet-Exercise-Induced Hypokalemic Metabolic Alkalosis. (https://pubmed.ncbi.nlm.nih.gov/32442511/). Hoorn EJ, Bovée DM, Geerse DA, Visser WJ. Am J Med. 2020 Nov;133(11):e667-e669. doi: 10.1016/j.amjmed.2020.04.019. Epub 2020 May 20.